Saturday, May 31, 2008

Depression,Inflammation And Antidepressant Response

Major depressive disorder is a common and complex condition that ifffects about 15% of the population of the US, yet very little is known about the methods behind the psychiatric disorder. What is known is that there are clinical parallels between depressive affections and the affections of certain inflammatory disorders.

Researchers from University of Miami (In findings published electronically in Molecular Psychiatry ) found polymorphisms in inflammation-related genes which are added with susceptibility to major depression and antidepressant response. Two genes,PSMB4 (proteasome beta 4 subunit) and TBX21 (T-bet), critical for T-cell function in the immune system have been added with susceptibility for major depressive disorder and antidepressant treatment response.The population of study was made up of 284 depressed Mexican-Americans(from Los Angeles ) who were already enrolled in a pharmacogenetic study of antidepressant treatment response. There were 331 individuals in the control group from the same community.

Ma-Li Wong, M.D., professor and vice chair for translational research in the Department of Psychiatry and Behavioral Sciences at the Miller School of Medicine ,said that this search suggest that a simple blood test to look for these genes could help us identify people who are at risk for depression and we would know to watch these people in stressful conditions, like a soldier in combat, and intervene earlier to get them the help they need.Genetic variations in PSMB4 and TBX21 may also be relevant to psoriasis and asthma. These disorders are known to be co-morbid with major depressive disorder and related to psychosocial stressors.

Posted by Tom at 10:34:54 | Permalink | No Comments »

Friday, May 30, 2008

Natural Cure For Depression

Depression can be an unpleasant experience. But simple natural cures are available for depression.Following are what you can do to naturally prevent depression:

  • Take a walk or exercise for at least a half-hour every day and learn to find the good in everything.
  • Live out with only positive health-oriented peopleand concentrate on the positive aspects of your life.
  • Eat an extremely healthy diet and don’t take high glycemic index carbohydrates, alcohol, fruit juices, caffeine products, processed vegetable oils and other foods high in refined sugars and unhealthy fats.
  • Drink plenty of water and eat a whole food diet with lots of colorful fruits and vegetables, whole grains, beans, lean poultry and fish high in omega 3 oils.
  • Keep your fat maintenance around 30% and make sure it comes mainly from healthy natural sources of whole grains, nuts, olive oil and fatty omega 3 fish.
  • B Complex has been proven need to both physical and emotional health.B vitamins are destroyed by alcohol, caffeine, nicotine, stress, processed foods and high glycemic sugars.
  • Vitamin C is essential for Stress, pregnancy, lactation, smoking and taking aspirin, tetracycline, and birth control pills .
  • Minerals, like calcium, magnesium, potassium, iron, manganese, selenium and particularly zinc, are necessary for stable moods and brain activity.
  • Omega 3 fish oil with EPA and DHA can cange your mood.
  • Good quality, pure fish oil capsules is a good safe, low calorie, low cost way to safely prevent and overcome ADHD, Alzheimer’s disease, depression and other brain-related conditions.
  • A highly respected and widely published journalist,Moss Greene is focusing on optimum health for the body, mind and spirit.
Posted by Tom at 10:15:18 | Permalink | No Comments »

Tuesday, May 27, 2008

Mental Health ‘RACISM’

Chief executive of an NHS Trust has claimed that by the cause of “institutional racism” in the health service, Asianpatients suffering depression and many other mental health problems are missing out on treatment .Women from south Asian backgrounds are twice as likely to commit suicide than the rest of theAntony Sheehan, “The mental health service had effectively chosen not to engage with the Asian community.We really should know impact of institutional racism is there in mental health and other health and social care services as well as it has been recognised in the criminal justice system.The real issue is just how we have chosen and not to connect with the community.”population, and there are concerns that this may be in part due to their failure to get help with mental problems.

According to chief executive of Leicestershire NHS Trust,Lord Patel of Bradford,the chairman of the Mental Health Act Commission,said to BCC,”Greater efforts are created to offer support to Asian communities but even they could suffer similar levels of problems to black African and Caribbean groups, which are vastly over-represented in mental health institutions. People from these ethnic groups are as much as 18 times more nearly to end up in a mental institution than the national average.System must be alert to signs that people from Asian backgrounds are also experiencing problems.If we neglect these messages in the next 10 to 20 years we wil see the same numbers of south Asian people ending up in the mental health system as young black African and Caribbean people are doing now, and that’s completely unacceptable in the 21st century.”

Posted by Tom at 07:11:53 | Permalink | No Comments »

Saturday, May 24, 2008

Alcohol & Depression

What’s different about alcohol for older people? As we get older, our bodies change. On the outside we notice lines, wrinkles, extra weight. Our skin is perhaps not quite as strong or flexible as it used to be. On the inside we:

  • lose muscle
  • gain fat
  • break down alcohol more slowly.

How much is it safe to drink? The more you drink, the more likely it is that alcohol will harm your health; BUT there are “sensible” levels of drinking which, for most people, are unlikely to be harmful. These are roughly:

  • 14 units of alcohol a week for women
  • 21 units for men

How many people drink too much? Older people tend to drink less alcohol than younger people, but even so 1 in 6 older men and 1 in 15 older women are drinking enough to harm themselves.

Are there any risks to “sensible” drinking? Just because we drink within the limits does not mean that it is safe. Very little research has been done on older people so we may be mistaken in thinking that these limits apply to everyone. There are also some particular problems:

  • health problems can make us more susceptible to alcohol
  • balance gets worse with age - even a small amount of alcohol can make you more unsteady and more likely to fall.

Alcohol can:

  • add to the effect of some medications, e.g. painkillers or sleeping tablets
  • reduce the effect of others, e.g. medication to thin the blood (warfarin) – alcohol can increase the risk of bleeding or developing a clot or blockage in your bloodstream.

What are the risks of drinking too much? Alcohol can damage nearly every part of the body:

  • the stomach lining → ulcers or bleeding
  • the liver → cirrhosis and liver failure
  • heart muscle → heart failure produces a build-up of fluid in the lungs which makes you breathless
  • cancer → of the mouth, stomach and liver
  • malnutrition→ alcohol has lots of calories for energy, but none of the protein, fats or vitamins you need to keep your body in good repair
  • sense of balance → falls and accidents
  • blackouts or fits
  • stroke


Isn’t drinking good for the heart? If you drink about 1 unit a day, you are slightly less likely to have a heart attack. This finding came from studies in men in their 40s and 50s - so it may not apply to everyone. It makes more difference to control your weight, take exercise and make sure that you get proper treatment for any high blood pressure, high cholesterol or diabetes.

How can alcohol affect mental health?Too much alcohol can cause:

  • Anxiety: This may be because you start to feel anxious as the alcohol wears off – like a mild withdrawal symptom. So you have a drink to feel better – but as the effect of that wears off, you start feeling anxious again.
  • Depression: You feel less hungry, have difficulty sleeping and get tired more easily. You start to feel that you have lost interest in things you used to enjoy, are slower to take things in when reading or watching television and feel less positive about the future - or even feel that life is not worth living.
  • Hearing voices: This is less common but can happen if you have been drinking heavily for a long time. It starts with vague noises, like leaves rustling, and gradually becomes distinct voices. These can be unpleasant and are usually distracting.
  • Confusion: If you have been drinking but not eating, the lack of Thiamine, an important vitamin, can make you confused and unsteady on your feet. If this is not treated urgently, you can get permanent damage to your short-term memory – this is called Korsakoff’s syndrome.
  • Dementia: You can lose your short-term and, as time goes on, your long-term memory.

How might an older person develop an alcohol problem? About a third of older people with drinking problems develop them for the first time in later life. Bereavement, physical ill-health, difficulty getting around and social isolation can lead to boredom and depression. Physical illness may be painful. It can be tempting to use alcohol to make these difficulties more bearable. It may then become part of our everyday routine and difficult to give up. Unlike younger people, there may be less pressure to give up drinking - there may be less family responsibilities, or no pressure to go to work each day.It is possible that health professionals don’t spot heavy drinking in older people as often as they should, because:-

  • Older people tend not to talk about their drinking, perhaps because of embarrassment.
  • They mistake the effects of alcohol for a physical or mental health problem.
  • They forget that older people may have drink problems so they don’t look so hard for it.

What help is available? It is often easier to treat drink problems in older people than it is in their younger counterparts.

Treatments include: Detoxification or ‘detox’, Support groups, Psychological or ‘talking treatments’,Acamprosate, Helping the problem

What do I do now? If you think that you have an alcohol problem, talk to your doctor. If necessary they can arrange for you to have tests, see a counsellor, or refer you to a specialist. There are also a number of organizations offering free advice for alcohol problems.

source: http://www.rcpsych.ac.uk

Posted by Tom at 10:27:54 | Permalink | No Comments »

Thursday, May 22, 2008

Depression : Under the Age of Four

According to the research in Scotland,there are dozens of children under the age of four for clinical depression.It has confirmed that more than 150 pre-school youngsters are being treated for the mental illness.In figures,93 girls and 62 boys were diagnosed as being clinically depressed.

Freedom to play: The Mental Health Foundation (MHF)believes the breakdown of family life , the pressures of modern living could be a great factors and the children are not given enough freedom to play and to develop at their own pace. It is also said that we cannot diagnose children with mental health problems as we do with adults.Parents should not be making their home diagnosis on such kind of mental health problems.They need to consult and to speak with professionals.Level of communication in children is not the same as grown ups, so we have to look out for signs.There are so many problems with eating and sleeping,being withdrawn and showing signs of anxiety.It must be stressed that a depressed child will have more than one of such problems and they will persist over a period of time.

Sense of right and wrong: After these factors ,properly diagnosed that a health professional would look at the home environment and problems( which might occur).All of these problems should be put in context and should recognise what the signs of good mental health in children are.Satisfied children will enjoy playing on their own as well as enjoy playing and learning with others. They will also have a sense of right/ wrong and they will learn how to remove and solve their own problems.

Scottish National Party MSP Adam Ingram said that I think this problem is clearly related to family break-ups and represents the levels of stress in our society today .We need more family support and to look clearly at how we organise ourselves.

Posted by Tom at 07:50:24 | Permalink | No Comments »

Tuesday, May 20, 2008

Pristiq : A New Treatment For Major Depressive Disorder

Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), announced that PRISTIQTM (desvenlafaxine), a new serotonin-norepinephrine reuptake inhibitor (SNRI) approved to treat adult patients with major depressive disorder (MDD), is now available in U.S. retail pharmacies nationwide. The recommended dose of PRISTIQ is 50 milligrams (mg) once daily. The Company begins full-scale selling and educational efforts regarding PRISTIQ for physicians this week. “We are proud to make PRISTIQ available as a new treatment option for the millions of American adults who struggle with depression,” comments Philip Ninan, M.D., Vice President, Wyeth Medical Affairs, Neuroscience. Dosage adjustment (50 mg every other day) is necessary, however, in patients with severe renal impairment or end-stage renal disease. PRISTIQ, an SNRI approved by the U.S. Food and Drug Administration on February 29, 2008, is an important new treatment option for the millions of adults in the United States who have MDD. Discovered and developed by Wyeth, PRISTIQ demonstrates the Company’s significant and continued commitment to developing new therapies in the field of neuroscience. At the recommended dose of 50 mg, the discontinuation rate due to an adverse experience for PRISTIQ (4.1 percent) was similar to the rate for placebo (3.8 percent) in clinical studies.

Major Depressive Disorder: Major depressive disorder (MDD) is a common mental disorder, affecting about 121 million people worldwide. In the United States, MDD affects approximately 15 million adults, or 6.7 percent of the U.S. population age 18 and older in a given year. In fact, depression is among the leading causes of disability and the fourth leading contributor to the global burden of disease. Further, a research study estimated that the total economic burden of depression was $83.1 billion in 2000, including direct treatment costs and suicide- and work-related costs.

Treatment Considerations: Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of PRISTIQ or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. PRISTIQ is not approved for use in pediatric patients. Contraindications. PRISTIQ is contraindicated in patients with a known hypersensitivity to PRISTIQ or venlafaxine. PRISTIQ must not be used concomitantly with an MAOI or within 14 days of stopping an MAOI. Allow 7 days after stopping PRISTIQ before starting an MAOI.

Warnings and Precautions:
• All patients treated with antidepressants should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the first few months of treatment and when changing the dose. Consider changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse or includes symptoms of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, mania, or suicidality that are severe, abrupt in onset, or were not part of the patient´s presenting symptoms. Families and caregivers of patients being treated with antidepressants should be alerted about the need to monitor patients.
• Development of a potentially life-threatening serotonin syndrome may occur with SNRIs and SSRIs, including PRISTIQ, particularly with concomitant use of serotonergic drugs, including triptans, and with drugs that impair the metabolism of serotonin (including MAOIs). If concomitant use is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases. Concomitant use of PRISTIQ with serotonin precursors is not recommended.
• Patients receiving PRISTIQ should have regular monitoring of blood pressure since sustained increases in blood pressure were observed in clinical studies. Pre-existing hypertension should be controlled before starting PRISTIQ. Caution should be exercised in treating patients with pre-existing hypertension or other underlying conditions that might be compromised by increases in blood pressure. Cases of elevated blood pressure requiring immediate treatment have been reported. For patients who experience a sustained increase in blood pressure, either dose reduction or discontinuation should be considered.
• SSRIs and SNRIs, including PRISTIQ, may increase the risk of bleeding events. Concomitant use of aspirin, NSAIDs, warfarin, and other anticoagulants may add to this risk. Mydriasis has been reported in association with PRISTIQ; therefore, patients with raised intraocular pressure or those at risk of acute narrow-angle glaucoma (angle-closure glaucoma) should be monitored.
• As with all antidepressants, PRISTIQ should be used cautiously in patients with a history or family history of mania or hypomania, or with a history of seizure disorder. Caution is advised in administering PRISTIQ to patients with cardiovascular, cerebrovascular, or lipid metabolism disorders. Increases in blood pressure and small increases in heart rate were observed in clinical studies with PRISTIQ. PRISTIQ has not been evaluated systematically in patients with a recent history of myocardial infarction, unstable heart disease, uncontrolled hypertension, or cerebrovascular disease.
• Dose-related elevations in fasting serum total cholesterol, LDL (low density lipoprotein) cholesterol, and triglycerides were observed in clinical studies. Measurement of serum lipids should be considered during PRISTIQ treatment. On discontinuation, adverse events, some of which may be serious, have been reported with PRISTIQ and other SSRIs and SNRIs. Abrupt discontinuation of PRISTIQ has been associated with the appearance of new symptoms. Patients should be monitored for symptoms when discontinuing treatment. A gradual reduction in dose (by giving 50 mg of PRISTIQ less frequently) rather than abrupt cessation is recommended whenever possible.
• Dosage adjustment (50 mg every other day) is necessary in patients with severe renal impairment or end-stage renal disease (ESRD). The dose should not be escalated in patients with moderate or severe renal impairment or ESRD. Products containing desvenlafaxine and products containing venlafaxine should not be used concomitantly with PRISTIQ.
• Hyponatremia may occur as a result of treatment with SSRIs and SNRIs, including PRISTIQ. Discontinuation of PRISTIQ should be considered in patients with symptomatic hyponatremia. Interstitial lung disease and eosinophilic pneumonia associated with venlafaxine (the parent drug of PRISTIQ) therapy have been rarely reported.

Adverse Reactions:The most commonly observed adverse reactions in patients taking PRISTIQ vs placebo for MDD in short-term fixed-dose premarketing studies (incidence ≥5% and twice the rate of placebo in the 50-mg dose group) were nausea (22% vs 10%), dizziness (13% vs 5%), hyperhidrosis (10% vs 4%), constipation (9% vs 4%), and decreased appetite (5% vs 2%).

source : http://www.medicalnewstoday.com

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Thursday, May 15, 2008

Depression in Older People

Introduction:Everyone feels sad sometirnes. In later life the reasons for becoming depressed do seem to be more common. We have to stop work and probably have less money. We may start to get the symptoms of arthritis or other physical problems. We may experience the death of a partner, or friends. But older people don’t feel depressed all the time. In fact less than 1 older person in 6 feels so depressed that they or others notice. Less than 1 in 30 older people have a ‘depressive illness’.

What is it like to have depression?
Feeling low or sad is not the only sign of depressive illness. These are some other common symptoms:
* A feeling of sadness, depression or being ‘down’ which is worse than normal sadness.
* A loss of interest in life - you can’t enjoy the things that usually give you pleasure.
* Feeling tired even when you’re not doing much. The simplest task seems a big effort. You just don’t feel like doing anything.
* Losing your appetite and often losing weight too.
* An inner feeling of restlessness, making it hard to rest or relax properly.
* You start to worry and feel anxious. Some people have always worried more than others but, if this is unusual for you, it may be a sign of depression.
* You want to avoid other people. You may feel snappy or irritable if people are around you.
* Poor sleep. You may wake early in the morning (at least an hour or two earlier than usual) and then be unable to get back to sleep again.
* Losing confidence in yourself. You may feel useless or a burden to others.
* Poor concentration.
* Feeling panicky.
* Loss of sexual feelings.
* Feelings of being bad or guilty. You may dwell on things from the past and may get things out of proportion.
* Thoughts of suicide - at some point most people with severe depression will feel like ending it all. These feelings should be taken seriously. They mean that help is needed. Sometimes they become so strong that a person will work out ways of harming themselves, and even make preparations. This is a sign that help is urgently needed.

Particular problems for older people:
Physical symptoms and depression: Some of the symptoms of physical illnesses may be similar to those of depression. For example, loss of appetite or disturbed sleep may also be caused by physical illnesses, like thyroid problems, heart disease or arthritis. If you do have depression, you will have many of the thoughts and feelings listed overleaf.

Long-term illness:You may find yourself getting much more distressed by a particular physical problem, even though it has not really changed. This too may be a sign of depression coming on. Treating the depression will not take away the physical problem, but it can make it more bearable.

Confusion and memory problems: Worry and agitation can interfere with your memory and make you feel and appear quite confused. In turn, this can make you more worried because you wonder whether you are becoming ’senile’. Just occasionally, severe depression can be mistaken for dementia (permanent loss of memory). If you are worried about your memory, the odds are that this is not the central problem. Depressed people are only too aware of not being able to remember things. People with dementia usually do not realise there is a problem. Dementia and depression are completely different. Don’t put off seeking help for fear of being declared ’senile’.

A new sense of loneliness:Living alone does not automatically make you depressed. Sometimes an older person may have become used to living alone but gradually develops a sense of loneliness which wasn’t there before, or was not so bad.

Getting help:
How do you know when it’s time to get help?If your feelings of depression:
* Are worse than you would expect.
* Have gone on for several weeks.
* Interfere with your life.
* Mean that you can’t face being with other people.
* Make you feel that life is not worth living.
* Are noticed by other people sometimes friends or family members spot the problem before you do.

What should you do?Speak to your GP or family doctor. GPs are quite used to helping people with depression and almost all of them have had training in how to deal with it. You are certainly not wasting your doctor’s time by asking for help with depression. If you can’t get out, ask your doctor to see you at home. It may help to have a friend or relative with you when you see your doctor.

I don’t want to bother the doctor - depression isn’t a real illness:
Older people tend to think more about physical symptoms than about feeling depressed. The reason for this may be that many older people were brought up not to bother the doctor unless they had a physical complaint. Sometimes the first sign of depression can be a constant worry about having a physical illness, even when your doctor can’t find anything wrong with you. If he or she tells you that you are actually depressed, it may feel as though you are being fobbed off. This isn’t the case. Depression is as deserving of help as any other physical illness. You may feel tempted to insist on more tests than the doctor thinks you need, but this may just delay starting the treatment that will really help you.

Why do people get depressed?
It is natural to ask why we might have become depressed. When we are depressed, we tend to blame ourselves, but this is because depression makes us see things in a very negative way. It can make us blame ourselves for things that we are not responsible for. Usually there is more than one thing causing a depression.

Painful events:Depression sometimes comes out of the blue. More often it is triggered by a distressing event, such as the death of a partner or close friend. Such things happen to most older people at some time, yet most don’t get depressed. It does seem that some people are more vulnerable by nature. They are likely to get depressed when faced by a difficult or painful situation. For example, women seem to be more likely to get depressed than men. It may be that depression in men is harder to spot because they are less likely to talk about their feelings.

Past depression:You are more likely to have a depressive illness if you have had one before.

Physical Illness:You may become depressed if you have a physical illness that has not been recognised, such as a problem with the thyroid gland. Your doctor can easily check these things out. Reaction to a physical illness Any physical illness can trigger depression. This can be something sudden, like a stroke. It can be long and disabling, like Parkinson’s disease. It may be several illnesses which have taken their toll over the years. Although this may make the depression more ‘understandable’, it doesn’t mean that it can’t be helped. This type of depression often responds very well to treatment.

Medicines:Depression can be a side-effect of some medications.

Helping yourself:
* Ask for help:Just because you are older, you don’t have to put up with being depressed.
* Try to get out:It can be difficult when you get older because of physical problems like stiff joints or swollen ankles, but it’s really worthwhile. Staying at home all the time can make you brood on things. This doesn’t help and can make you feel more helpless and depressed. So, if family or friends offer, let them help you to get out. If you go to a day centre, they may have their own transport that you can use.
* Try to eat properly:People who are depressed often lose their appetite and eat very little. You can lose weight and run short of important vitamins and minerals. This can affect your health -older bodies cannot adjust as well as younger ones. Beware of stocking up on chocolate and biscuits - these are quick and easy to eat, but they don’t have the vitamins and minerals to keep you feeling well.
* Keep reminding yourself that you are ill:You are not being lazy or letting other people down.
* Keep reminding yourself that the vast majority of people get better
* Tell someone if you feel so low that you feel like ending it all
* Try not to keep your feelings to yourself:You’ll find yourself going over the same worries again and again. Talking to somebody does help.
* Try not to use alcohol to make you feel better:It can actually make depression worse. It may also react with any tablets you are taking.
* Try not to panic about not sleeping properly:It will get better when the depression lifts.
* Try not to alter the number of tablets you are on, or stop taking them, or try other remedies, without discussing it with your doctor. If the tablets have unpleasant effects, tell your doctor or nurse.
* Try not to think that depression makes people senile or leads to dementia:It doesn’t.

Medical treatments for depression:
Antidepressants:
If you happen to be so depressed that you have physical symptoms, such as poor sleep, poor appetite and loss of weight, or the depression has gone on for a long time, your doctor will often suggest an antidepressant. About 50-60% of people who take these tablets will find them helpful. There are several different types of antidepressant now available, so there should be no difficulty in finding one to suit you.

How do antidepressants work?It is thought that antidepressants boost the levels of two chemicals in the brain that get stifled in depression. These chemicals are called serotonin (also called 5HT), and noradrenaline.

Do antidepressants have side effects?Modern antidepressants are very safe. Some can make you feel sick or more anxious over the first few days, but these effects usually wear off. Others may make you sleepy or give you a dry mouth. They can sometimes interfere with other medicines that you are taking, but your doctor will be aware of this. About one in three people get mild withdrawal symptoms if they stop these medicines suddenly. So it’s best to come off them slowly.
Antidepressants usually take one or two weeks to start working although they may improve your sleep quite quickly. You may find that it takes 6 to 8 weeks for them to really make a difference. Many antidepressants slow down your reactions and may make you a bit drowsy. It is important not to drive if this happens to you. If you take several sorts of pills, you may find that you get muddled and forget to take some of your medicines. If so, your doctor, chemist or community nurse can help. They can give you a special box, or blister pack, with all the tablets set out for you to take at the right time of the day for a whole week.

Talking treatments for depression:It can be a great relief to ‘off-load’ to a sympathetic, understanding, uncritical listener. This could be a friend, a relative, a volunteer or a professional. There are more specialised psychological, or talking treatments.

Psychotherapy helps you to understand depression in terms of what has happened to you in the past.

Cognitive Behavioural Therapy tries to help you think in ways that make you feel better. These can be arranged through your GP, a community psychiatric nurse, psychologist or psychiatrist.If your depression has been triggered by a bereavement or problems in a relationship, then bereavement counselling or marriage therapy can help.

Are there problems with talking treatments?
Medical Treatments for Depression:They are very safe. However, sometimes psychotherapy can bring up unhappy memories from the past. A good therapist will know how to deal with this. If you have concerns, you should discuss them with your doctor or therapist.

Practical help:You may become depressed because you are living in poor housing or not happy in your neighbourhood. If so, a social worker may be able to help you move but, a word of warning, it is important not to make a decision about moving when you are still depressed. You may regret it when you are feeling better. Professionals can also help with finding ways to occupy you and to spend time with other people. This can be very important because many people become quite isolated when they are depressed and find it hard to get back into the swing of things. There are lunch clubs, day centres and support groups where you can go. Some of them are just for older people with depression.It’s really important to talk to other people because it can make you feel better and it is less likely that your depression will return.

Which treatment is best?Everyone can try the simple steps in this leaflet. Talking treatments and antidepressants work equally well. Your doctor is more likely to recommend antidepressants if your depression is severe or has gone on for a long time. Antidepressants also work a bit faster than talking treatments. Some people prefer to try and get over the depression without medicine, whilst others prefer taking tablets. You can have both talking treatments and antidepressants. Your GP will be able to give you advice. It is also sometimes helpful to talk over the options with your family or a close friend.

What if depression is not treated?Most people will get better, after weeks, months or even a year or two, but the shorter the depression lasts, the better. The simple steps outlined in this leaflet may be enough to help you feel well again. If the depression is very severe, it may lead to a person taking their life or becoming very ill through not eating and drinking enough.

Seeing a psychiatrist:Although most people get better at home with these treatments, some people do not. If this happens, your family doctor may ask a psychiatrist to see you for some expert advice. That does not mean that people think you are ‘mad’. Your doctor may need a second opinion or advice about the best treatment in a particular case. Nowadays, most parts of the country have specialists (called ‘psychogeriatricians’ or ‘old age psychiatrists’) who are experts at treating older people with depression. They often work as part of a team, so you may see a nurse or a social worker first.
The first interview with a psychiatrist usually takes about an hour. If you are depressed, you may find it difficult to remember some of the details of how it all began. So ask a friend, neighbour or close relative to be present with you. It will help the psychiatrist to help you if he or she can get a complete picture of the situation.

Going into hospital:A small number of people need to have their depression treated in hospital. If you are very unwell -perhaps unable to eat or drink, or have tried to kill yourself - you might need to have ECT or electroconvulsive therapy. If recommended, you will need to discuss this thoroughly with your relatives and doctors. If you are unwilling or unable to give consent to this, an independent doctor would be asked to see you to decide if it is really necessary.

Staying well:It’s important to stay well and try to make sure it doesn’t happen again. For this reason you should not stop any tablets for depression until your doctor advises you to. Even if you are feeling normal, there’s a chance of the depression returning if you stop taking your tablets too quickly.If your general health is good and this is your first bout of depression, you will probably need to stay on the tablets for 6 to 12 months. If you have already had depression several times, your doctor may recommend that you stay on an antidepressant drug for longer. This has been shown to cut down the number of further bouts of depression.

For relatives and friends - how can you help?
* If you think that your friend or relative is becoming depressed, encourage them to accept help. You may be the first person to notice the depression. Your friend or relative will need to hear that depression is quite common and that it usually gets better. They may need to be reassured that they are not “going mad”. The first port of call should be their GP, who may be able to start their treatment.
* It may often be enough to show your concern by just being there with them.
* Older people with depression get tired very easily. It’s particularly helpful to offer some practical help, like shopping or cleaning for them. They may need reminding to eat properly.
* Don’t force your friend or relative to talk. Don’t bully them into doing things. Although it can help to get out and do some gentle exercise, it may not help if you have to nag them to do it. In fact, people will often dig their heels in if they feel they are being put under too much pressure.
* Be patient. Older depressed people may constantly ask for reassurance or become convinced that they’ve got something physically wrong with them. It’s often because they are frightened or don’t understand what is happening to them. Reassure them as much as you can and try to spend time listening. Point out that they are not ‘going senile’ or demented. People who have had depression are no more likely to get senile dementia than anyone else.
* Don’t be embarrassed to ask if your friend or relative has felt suicidal. It’s a myth that talking about it makes it more likely that someone will do it.
* Suicidal thoughts are a clear sign that help is needed. Most people who feel like this are relieved when someone asks about it.
* Caring for someone with depression can be exhausting. If you are getting worn out by everything, ask for help. Community Psychiatric Nurses can help you by arranging for your relative to go to a day centre or day hospital to give you a break. They can also help by being there for you to talk to.
* Finally, don’t make decisions about housing or accommodation when someone is depressed. Your friend or relative may put pressure on you and say that how they feel is all to do with where they live. But things are not usually that simple. Many older people who move when they are depressed may regret it once they are better.

source : http://www.rcpsych.ac.uk

Posted by Tom at 07:54:47 | Permalink | No Comments »

Friday, May 9, 2008

Teenage-Depression

Teenage depression isn’t just bad moods and occasional melancholy. Depression is a serious problem that impacts every aspect of a teen’s life. Left untreated, teen depression can lead to problems at home and school, drug abuse, self-loathing—even irreversible tragedy such as homicidal violence or suicide. Fortunately, teenage depression can be treated, and as a concerned parent, teacher, or friend, there are many things you can do to help.

Understanding teen depression: There are as many misconceptions about teen depression as there are about teenagers in general. Yes, the teen years are tough, but most teens balance the requisite angst with good friendships, success in school or outside activities, and the development of a strong sense of self. Occasional bad moods or acting out is to be expected, but depression is something different. Depression can destroy the very essence of a teenager’s personality, causing an overwhelming sense of sadness, despair, or anger.
Whether the incidence of teen depression is actually increasing, or we’re just becoming more aware of it, the fact is that depression strikes teenagers far more often than most people think. And although depression is highly treatable, experts say only 20% of depressed teens ever receive help. Unlike adults, who have the ability to seek assistance on their own, teenagers usually must rely on parents, teachers, or other caregivers to recognize their suffering and get them the treatment they need. So if you have an adolescent in your life, it’s important to learn what teen depression looks like and what to do if you spot the warning signs.

Signs and symptoms of teen depression: Teenagers face a host of pressures, from the changes of puberty to questions about who they are and where they fit in. The natural transition from child to adult can also bring parental conflict as teens start to assert their independence. With all this drama, it isn’t always easy to differentiate between depression and normal teenage moodiness. Making things even more complicated, teens with depression do not necessarily appear sad, nor do they always withdraw from others. For some depressed teens, symptoms of irritability, aggression, and rage are more prominent..

SIGNS AND SYMPTOMS OF DEPRESSION IN TEENS:

* Restlessness and agitation
* Feelings of worthlessness and guilt
* Lack of enthusiasm and motivation
* Fatigue or lack of energy
* Difficulty concentrating
* Thoughts of death or suicide
* Sadness or hopelessness
* Irritability, anger, or hostility
* Tearfulness or frequent crying
* Withdrawal from friends and family
* Loss of interest in activities
* Changes in eating and sleeping habits

If you’re unsure if an adolescent in your life is depressed or just “being a teenager,” consider how long the symptoms have been present, how severe they are, and how different the teen is acting from his or her usual self. While some “growing pains” are to be expected as teenagers grapple with the challenges of growing up, dramatic, long-lasting changes in personality, mood, or behavior are red flags of a deeper problem.

source : http://www.helpguide.org

Posted by Tom at 07:30:19 | Permalink | No Comments »

Tuesday, May 6, 2008

Medications for Depression

The major classes of antidepressant medication are the selective serotonin re-uptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), the monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants. SSRI medications affect levels of serotonin in the brain. For many people, these medications are the first choice. Examples of these medications are listed here. The generic name is first, with the brand name in parentheses. These drugs are best known by their brand names.

* Fluoxetine (Prozac)
* Sertraline (Zoloft)
* Paroxetine (Paxil)
* Fluvoxamine (Luvox)
* Citalopram (Celexa)
* Escitalopram (Lexapro)

TCAs
are often prescribed in severe cases of depression or when SSRI medications don’t work. Like the SSRIs, most of these are better known by their brand names.

* Amitriptyline (Elavil)
* Clomipramine (Anafranil)
* Desipramine (Norpramin)
* Doxepin (Adapin)
* Imipramine (Tofranil)
* Nortriptyline (Pamelor)
* Protriptyline (Vivactil)
* Trimipramine (Surmontil)

The MAOIs are not used as often since the introduction of the SSRIs. Because of interactions, the MAOIs may not be taken with many other types of medicines, and some types of foods that are high in tyramine (like aged cheeses, wines, and cured meats) must be avoided as well.

* Phenelzine (Nardil)
* Tranylcypromine (Parnate)

The atypical antidepressant medications work differently than the commonly used SSRIs. These medications may be prescribed when SSRIs have not worked.

* Bupropion (Wellbutrin)
* Mirtazapine (Remeron)
* Nefazodone (Serzone)
* Trazodone (Desyrel)
* Venlafaxine (Effexor)

One-half to two-thirds of people who take antidepressant medications get better. It may take anywhere from one to six weeks to start feeling better. Don’t give up taking the medication if you don’t feel better right away.Your health-care provider will see you again during this period to see if your body is tolerating the medication and if your symptoms are better. If they are not, he or she may adjust your dose or prescribe a different medication.Even after you feel better, you should continue to take the medication for six to nine months.

 

source: http://www.emedicinehealth.com

Posted by Tom at 11:21:43 | Permalink | No Comments »

Friday, May 2, 2008

Prevention of Postpartum Depression

People can’t prevent the postpartum hormone changes that cause postpartum blues, you can take steps to prevent ongoing postpartum depression (PPD).

Basic steps for prevention measures for every woman:

To minimize the effects of postpartum hormonal changes and stress, keep your body and mind strong.

• Ask for help from others, so you can get as much sleep, healthy food, exercise, and overall support as possible.
• Stay away from alcohol, caffeine, and other drugs or medications unless recommended by your health professional.
• Close monitoring after childbirth is important. If you are worried about developing PPD, have your first postnatal checkup 3 or 4 weeks after childbirth, rather than the usual 6 weeks.2

Prevention measures for high-risk women

If you have suffer from depression or postpartum depression before, you and your health professional can plan ahead to reduce your higher risk of postpartum depression. Consider the following options if you have:

• A history of depression. If you have no depressive symptoms late in a first pregnancy, watchful waiting is recommended. However, if you have a history of severe depression, some experts recommend counseling and support before childbirth. You and your health professional may choose to start antidepressant medication after the birth to prevent PPD.

Should I take antidepressants during pregnancy?

• A history of PPD. After childbirth, don’t wait till symptoms develop-start with counseling and support (some women start counseling a couple of months before childbirth).

• Depression during pregnancy. If you are taking an antidepressant medication during pregnancy, continue taking it into the postpartum period to reduce your high risk of postpartum depression.

Posted by Tom at 07:24:39 | Permalink | No Comments »